There is special field “Arguments” for Chrome browser in project settings. You can add your arguments for running Chrome browser as shown on the screenshot below:

Full list of arguments can be found from the links bellow:
https://peter.sh/experiments/chromium-command-line-switches/#reduce-security-for-testing
https://www.chromium.org/developers/how-tos/run-chromium-with-flags

You need to restart project to apply arguments change in project settings.
Arguments can also be used in action block Browser>Setting>Run instance.